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DR, other anti-aging therapies such as metformin treatment, and long-lived species compared to related short-lived species have been found to show decreased ETC complex I activity or decreased levels of ETC complex I membrane arm subunits such as NDUFV2 (Gómez et al., 2023

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Therefore, activating GPX4 and GSH to inhibit ferroptosis is an attractive option for cardiac disease therapy (Fig